Anti-MSR1 Polyclonal Antibody

品牌：solarbio | 货号：K000359P

商品货号：	商品品牌：	规格	基本售价：	选择规格
K000359P-50ul	solarbio	50ul	960.00元
K000359P-100ul	solarbio	100ul	1600.00元

英文名称	Anti-MSR1 Polyclonal Antibody
别名	CD204;SCARA1;SR-A;SR-AI;SR-AII;SR-AIII;SRA;phSR1;phSR2
应用	WB IHC IF
稀释比例	WB 1:500-2000. IHC 1:50-200. IF 1:10-100.
交叉反应	Human Mouse
蛋白分子量	50kDa
Gene ID	4481
保存	Store at -20°C. Avoid freeze / thaw cycles.
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
纯化方法	Affinity purification
亚型	IgG
免疫原	Recombinant protein of human MSR1
性状	液体
Public Immunogen Range	Recombinant protein of human MSR1
Subcellular Locations	Membrane Single-pass type II membrane protein
Swiss Prot	P21757
克隆类型	Polyclonal Antibody
背景资料	This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.